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The next-generation emollient therapy that sustainably lowers your skin’s pH to optimally rebuild its protective barrier The next-generation emollient therapy that sustainably lowers your skin’s pH to optimally rebuild its protective barrier

An intensive therapy for eczema-prone skin

Ceradan® Advanced combines ceramide-dominant emollients with a novel, patented skin pH buffering formulation to give rapid relief in eczema-prone skin.

It offers an exciting new approach that benefits eczema-prone skin conditions in two ways:R1

  1. Sustainably lowers skin pH
  2. Replenishing the ceramide deficiency that occurs in eczema-prone skin

Working together, the formulation in Ceradan® Advanced targets the two main issues in this condition which are an increased skin pH that leads to ceramide depletion and compromised skin barrier.

Learn More About The Importance Of Normal Skin pH And Ceramides

How does acidification of skin pH bring added rapid relief to eczema-prone skin?

The natural, healthy skin pH is between 4-6. When the skin is unable to maintain its acidity due to overexposure to various factors (e.g. use of harsh soaps for a long duration or due to increasing age), the pH starts to increase, and the acid mantle progressively weakens.

There is mounting evidence that application of acidic emollients on eczema-prone skin helps the condition.R2 Lactobionic acid (LBA) is a safe and known alternative to older generation alpha hydroxy acids that shows lower irritation potential, strong antioxidant properties and skin mositurising activity.

As it is acidic in nature, LBA is also able to reduce the skin’s pH as shown in the Figure below.R2

How-Ceradan-Advanced-works-1

Figure 1: The graph shows the amount of pH change experienced in the skin of healthy volunteers when LBA (L) or a placebo (P) was applied. LBA significantly reduced the pH (* p < 0.05) while the placebo raised the pH slightly. Adapted from Tasic-Kostov Met al 2019

In a study on rats induced with eczema-like condition used vinegar and hydrogen chloride (acids) showed the rats that were treated with them had improvement in eczema-like symptoms compared to those who were not. These improvements included:R3

  • Reduction of total epidermal water loss
  • Increase in skin hydration
How-Ceradan-Advanced-works-2

Figure 2: Acids like vinegar (Vin) and hydrogen chloride (HCl) showed reduction in total epidermal water loss (TEWL) indicating improvement in skin barrier function and improved stratum corneum (SC) hydration. Adapted from Lee 2016

In a separate study, eczema-like conditions were induced in a group of rats. These rats were then grouped into those that were treated with neutralised LBA (nLBA), ethanol and water (vehicle) or LBA. Rats treated with LBA showed significant improvements in:R4

  • Barrier function
  • Skin pH
  • Surface hydration
How-Ceradan-Advanced-works-3

Figure 3: Improvement of skin barrier function indicated by significant reduction of total epidermal water loss (TWEL), reduction in surface pH and increase in surface hydration with LBA compared to vehicle (ethanol + water) and nuetralised LBA. Adapted from Hatano Y et al 2009

The challenges in currently available emollients

Emollients are recommended in supporting the improvement of eczema-prone conditions.R5 The recent advancement of including ceramide-dominant lipid-based formulations into emollients helps address the issue of ceramide deficiency in this condition. The basic mechanism of these formulations essentially involves penetration into the stratum corneum, inclusion of ceramides in the lamellar bodies within the keratinocytes which then secretes the ceramides back into the stratum corneum. The overall effect is the replenishment of ceramides into the skin, reduction of inflammation and restoration of the skin’s barrier function.R3, R6

Most emollients in the market today are formulated with ingredients to reach an acceptable acidic pH. However, the production process needs to balance the formulation with product safety concerns and shelf-life. Therefore, buffering agents are included, which then to increase the end pH of these products. This usually means the acidification on the skin becomes insignificant.R7

How is Ceradan® Advanced unique?

All of Ceradan® range of products contain a unique combination of ceramides:cholesterol:fatty acid ratio of 3:1:1, the ceramide concentration three times more than the other two lipids responsible in skin barrier integrity. This mimics that of the physiological lipids in the skin,R8-R10 and effectively addresses the lack of ceramides in eczema-prone skin to support accelerated optimal skin barrier repair.R11-R13

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Figure 4: Effect of Ceradan® unique 3:1:1 ratio that helps in the accelerated repair of the skin barrier

Ceradan® Advanced dual-action formulation combines the unique 3:1:1 ratio and a novel patent-pending sustainable skin pH lowering technology.

Its formulation contains zinc LBA that is low in pH, to encourage acidification of the skin and has been developed to:R1

  • Be stable at low pH
  • Impart a sustained reduction in skin pH
  • Reduce pH deep within the stratum corneum
  • Be mild
  • Inhibit protease activity
  • Have cosmetic acceptability
How-Ceradan-Advanced-works-5

Figure 5: Ceradan® Advanced novel patent pending technology uses zinc LBA with an enhanced delivery system to not only maintain the low pH of the formulation but also impart a sustrained reduction in skin pH. Data on file.

This technology’s unique buffering system is able to lower the skin pH to 4-6, sustainably for up to 12 hours. It does this through a unique emulsifier system for a stable environment so that the formulation maintains a slightly acidic pH level.R1

How-Ceradan-Advanced-works-6

Figure 6: When Ceradan® Advanced (pink line) was tested against other emollients, it showed a sustained lowering of skin pH over 12 hours compared to the rest. Data on file.

Due to its sustained lowering of skin pH, Ceradan® Advanced is able to protect the pH of eczema-prone skin when exposed to alkalinising soap and water, maintaining the skin pH to its normal 4-6 range.R1

How-Ceradan-Advanced-works-7

Figure 7: The skin pH on the palm (pink bars) and back of hand (blue bars) were tested prior to washing with soap, after washing with soap, application of Ceradan® Advanced and finally after washing with soap post-application of Ceradan® Advanced. The skin’s pH after application of the product was maintained at an acceptable, normal range of < 6 compared to washing without its application. Data on file

Learn more about Ceradan® Advanced

Soothing gel can help calm the skin.

Lennix is super sensitive to mosquito bites not only does it swells up to the size of golf balls but when he scratches it ….
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Joanne

Singapore

Ceradan Hydra moisturiser is able to maintain the hydrated.

Having eczema since I was 2 weeks old at birth, I’ve been on the search for products to keep the eczema under control ….
Read More

Cheryl

Singapore

It’s soap free and safe for all skin types

Honestly though, this 3 are my most used products from @ceradan311sg ? I love using the wash on Shayera & Zayne as ….
Read More

Jane

Singapore

It’s a very gentle and baby-safe product.

We were introduced to Ceradan Skin Barrier Repair Cream by Marc’s paediatric when he started to develop a neck rash from all the sweating, milk and drool ….
Read More

Cheryl

Singapore

It is hypoallergenic and 100% safe for newborn.

My baby is almost 2 months old, for the past weeks, I’ve been overwhelmed by frequent diaper changing and feeding my baby day and night ….
Read More

Adeline

Singapore

Ceramoz will make your life better!

Recommended by a pediatric dermatologist, my 4 YO girl has been using the Ceramoz for more than 2 years now. It is truly the best of both worlds ….
Read More

Alfred

Singapore
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  • Lennix is super sensitive to mosquito bites not only does it swells up to the size of golf balls but when he scratches it he gets a bacterial skin infection which either lands him in hospital for IV antibiotics or heavy doses of oral antibiotics.

    So now whenever he gets bitten we immediately apply antiseptic solution and then put a bandaid on it so he wouldn’t be able to scratch.

    However the area around the bite becomes very dry and scabby possibly due to lack of air because we leave the bandaid on until the bite heals? We have been using @ceradan311sg soothing gel to help calm the skin so scratching is minimised to prevent further damage and it’s been working great! We ❤️ it!

  • Having eczema since I was 2 weeks old at birth, I’ve been on the search for products to keep the eczema under control. One thing I found useful before attending this session is that I “drink” moisturisers by the bottle and only came to know Ceradan since Marc was born. What I didn’t know was Ceradan is great for all ages, all skin types, especially dry, sensitive and eczema ones.

    The texture of the Ceradan Hydra moisturiser is very light yet is able to maintain the hydrated feeling for quite a while. And understanding from Dr Lynn that the key issue with eczema skin is to build up the skin’s barrier to minimise inflammation and infection, using a moisturiser with 3:1:1 ceramide dominant ratio is essential.

  • Honestly though, this 3 are my most used products from @ceradan311sg ? I love using the wash on Shayera & Zayne as it puts my mind at ease knowing that it’s soap free and safe for all skin types. As for the diaper cream, I use it on the kids even when there’s no rash to ensure that they’re protected. I used it on myself the other day when I had a minor rash on my hand and it helped! As for Ceramoz, it’s part mosquito repellent and part moisturiser! It’s the kiddos must have when they go over to my in-laws place which is a landed space, so you know how mosquitos love to party inside.?

  • We were introduced to Ceradan Skin Barrier Repair Cream by Marc’s paediatric when he started to develop a neck rash from all the sweating, milk and drool in between his neck folds. And later, when Marc started on his helmet therapy, the orthopaedic suggested using Ceradan Body Wash to help minimise any possibility of heat rashes and keep his skin moisturised.

    Having used Ceradan products on Marc for quite a while now, we do find that it’s a very gentle and baby-safe product. Upon using the Ceradan Skin Barrier Repair Cream, his neck rash was under control very quickly and it’s been very effective even for myself when I have eczema flare ups. Ceradan Regimen, which consists of Ceradan Skin Barrier Repair Cream and Ceradan Body Wash, is suitable for children as young as newborns and it has demonstrated clinically-proven efficacy in a study conducted by KK Women’s and Children’s Hospital and National Skin Centre in Singapore to prevent 1 in 2 eczema flares in Singapore children.

    Since Marc loves swimming, and the chlorine in the water is very drying for the skin, I highly recommend Ceradan Body Wash to cleanse and maintain his gentle baby skin as hydrated as possible.

  • My baby is almost 2 months old, for the past weeks, I’ve been overwhelmed by frequent diaper changing and feeding my baby day and night. ?‍♀️?? Diaper rash is also every mum’s nightmare so choosing the right diaper cream is so important. Ceradan’s diaper cream is clinically proven and also recommended by KK Children & Women’s Hospital.

    It is hypoallergenic and 100% safe for newborn.

    I’m thankful to be able to try out this diaper cream for my baby with its unique triple protective actions◾Zinc oxide to seal out wetness ◾Octenidine to control yeast overgrowth ◾Contains 3:1:1 ratio of ceramic, cholesterol and free fatty acids to repair skin barrier.

    Thanks for keeping my baby’s skin rash-free!

    Ceradan is available at Watsons, Guardian and Unity stores.

  • Recommended by a pediatric dermatologist, my 4 YO girl has been using the Ceramoz for more than 2 years now. It is truly the best of both worlds, being able to moisturise and protect against mosquito bites at the same time!

    One big problem we had to deal with when my girl started childcare was mosquitoes ?. Doesn’t help when she had eczema and very sensitive skin. One bite on her and the bitten site would swell and become inflamed. Mosquito patches don’t work at all, and kid-friendly insect repellents either don’t work so well, or are too “spicy” – imagine the whines when she accidentally rubs her eyes after applying the repellent. When we were initially introduced to Ceramoz, we were a bit doubtful but later glad to learn that my girl don’t get bitten by mosquitoes that often anymore! (Truth he told, she only gets bitten when she forgets to apply it after her shower in childcare). It has proved its use so much that I use it now even during her non school days, 2+ years and counting!

    If you have a school-going child with eczema conditions, delicate skin, or is simply a mosquito magnet, Ceramoz will make your life better!

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